226-Day Rule: The Law of Circadian Clock on Immunity
226-Day Rule: The Law of Circadian Clock on Immunity
Regardless of natural infection or vaccination, a common phenomenon is that an epidemic wave may occur about 226 days (±25 days) after an epidemic wave or vaccination. 226 days is exactly 365 days (a year) divided by the golden ratio (365/1.618=226).
The immune system has such a circadian clock: in some regions (subtropical or temperate), the immunity of the population has two weak periods (troughs) every year, and the time interval of the two troughs is about 226 days.
For COVID-19, the immune system should also have such a circadian clock: the population gains immunity after infection of COVID-19 or vaccination, and the immunity against COVID-19 drops to a minimum after about 226 days.
In several waves of epidemics in many countries around the world, there is a 226-day rule. Some of these epidemics are caused by several factors such as the immune system's circadian clock, seasonal changes, and the emergence of variants. Some epidemics are mainly caused by the circadian clock of the immune system.
Vaccines work by simulating an infection in the body, so there is also a 226-day rule. Furthermore, because everyone is vaccinated at the same dose, the 226-day rule is more common. This results in a surprising similarity between the vaccination curve and the infection curve after 226 days.
The time interval between the two waves of epidemics in India, Brazil and Argentina was 234, 241 and 214 days, respectively.
Before mass vaccination, there were two peaks of the epidemic waves with a time interval of about 226 days in many countries.
In some countries with low vaccination rates, such as Russia, Ukraine, Poland, Romania, and Mexico, the time interval of the two epidemic waves this year is about 226 days.
Despite the low testing rate on the African continent, the 226-day phenomenon still exists in some African countries, such as Egypt, Ethiopia, and Nigeria.
There are also some special phenomena in a few countries, such as South Africa, where each adjacent wave of epidemics is about 170 days apart.
The peak on the vaccination curve usually has a corresponding peak on the infection curve, and the time intervals between the two peaks is also about 226 days. The time interval depends on the kind of vaccine and which dose to inject.
From January to April 2021, the vaccination curve of UK has 4 main peaks and 1 trough, which all have corresponding peaks and trough on the infection curve. The time intervals between the 4 pairs of peaks and 1 trough range from 211 to 216 days.
From January to April 2021, the vaccination curve of Turkey has five main peaks, corresponding five main peaks on the infection curve. Except the first pair of peaks, the time intervals between other four pairs of peaks range from 230 to 239 days.
The time intervals between the two pairs of peaks on the curves of Singapore are all 202 days. The promotion of booster shots in Singapore may delay the appearance of the corresponding infection peaks of the vaccination peaks after 5/20.
The time intervals between the three pairs of peaks on the curves of Serbia range from 224 to 234 days. The booster shots may also delay the appearance of the corresponding infection peaks of the vaccination peaks after 3/14.
